Which of the following is a common administration route for naloxone?

Naloxone, an opioid antagonist, is commonly administered intranasally due to its effectiveness and ease of use. This route allows for rapid absorption into the bloodstream through the nasal mucosa, providing a quick reversal of opioid overdoses. Additionally, the intranasal route is particularly advantageous in emergency situations since it does not require needles, reducing the risk of needle-stick injuries and making it easier for bystanders or non-medical personnel to administer.

While naloxone can potentially be given by other routes, the intranasal option is favored in many community settings and emergency response protocols. The oral route would typically not be effective for naloxone, as the drug would undergo significant first-pass metabolism before reaching systemic circulation. Subcutaneous administration is less common in emergency scenarios for naloxone. Topical routes are also not standard for this medication, as naloxone does not have appropriate formulation for transdermal effectiveness. Therefore, intranasal delivery stands out as the most common and practical method for naloxone administration in both professional and public health contexts.